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Primary immunodeficiency (PI)PI refers to a group of rare, genetic disorders that impair the immune system. These diseases may be chronic and debilitating.1 Without a functional immune response, PI patients may be subject to infections, some of which can be fatal. PI diseases may be diagnosed in infancy, childhood, or adulthood, depending on disease severity. Common manifestations of PI include ear infections, sinus infections, pneumonia, bronchitis, meningitis, skin infections, and thrush.1,2Materials

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  1. Primary immune deficiency diseases (PIDDs). National Institute of Allergy and Infectious Diseases. Accessed May 31, 2022.
  2. Primary immunodeficiency (PI). Centers for Disease Control and Prevention. Accessed May 31, 2022.

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